Acquired Bartter-like Syndrome presenting with Polyuria and Reversible Hypokalemia associated with Colistin Use in a Critically Ill Pediatric Patient

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Yavas D. P., EKİNCİ F., Horoz O. O., Gundeslioglu O. O., ATMIŞ B., Yildizdas D.

INDIAN JOURNAL OF CRITICAL CARE MEDICINE, vol.25, no.7, pp.822-824, 2021 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.5005/jp-journals-10071-23898
  • Journal Name: INDIAN JOURNAL OF CRITICAL CARE MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database
  • Page Numbers: pp.822-824
  • Keywords: Bartter-like syndrome, Colistin, Hypokalemia, Pediatric, Polyuria
  • Çukurova University Affiliated: Yes

Abstract

We report a case of an acquired Bartter-like syndrome (BLS) after 3 days of treatment initiation and improved after discontinuation of colistin therapy in pediatric intensive care unit. A 2-month-old girl with spinal muscular atrophy type 1 who had respiratory distress received colistin therapy with a dose of 5 mg/kg/day for Acinetobacter baumannii complex isolation from endotracheal aspirate on the 12th day follow-up. Polyuria (6 mL/kg/hour) in the presence of normal blood pressure and hypokalemic metabolic alkalosis were developed on the 3rd day of colistin treatment. Colistin was stopped on the 4th day, and 2 days after discontinuation of colistin, polyuria improved dramatically. Her metabolic alkalosis and hypokalemia discontinued after 2 and 4 days, respectively.