Ultrasound Accelerated Thrombolysis May Be an Effective and Safe Treatment Modality for Intermediate Risk/Submassive Pulmonary Embolism

Creative Commons License

ÖZMEN Ç., DENİZ A., Akilli R. E., DEVECİ O. S., ÇAĞLIYAN Ç. E., Aktas H., ...Daha Fazla

INTERNATIONAL HEART JOURNAL, cilt.57, sa.1, ss.91-95, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1536/ihj.15-271
  • Dergi Adı: INTERNATIONAL HEART JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.91-95
  • Anahtar Kelimeler: Right ventricular dysfunction, Circulatory collapse, Hypotension, HEMODYNAMICALLY STABLE PATIENTS, CATHETER-DIRECTED THROMBOLYSIS, DEEP-VEIN THROMBOSIS, NATURAL-HISTORY, MANAGEMENT, ALTEPLASE, THERAPY, HEPARIN, ECHOCARDIOGRAPHY, DYSFUNCTION
  • Çukurova Üniversitesi Adresli: Evet

Özet

Pulmonary embolism (PE) is a potentially life-threatening condition and the fact that 90% of PE originate from lower limb veins highlights the significance of early detection and treatment of deep vein thrombosis. (1)) Massive/high risk PE involving circulatory collapse or systemic arterial hypotension is associated with an early mortality rate of approximately 50%, in part from right ventricular (RV) failure.(2)) Intermediate risk/submassive PE, on the other hand, is defined as PE-related RV dysfunction, troponin and/or B-type natriuretic peptide elevation despite normal arterial pressure. (3)) Without prompt treatment, patients with intermediate risk PE may progress to the massive category with a potentially fatal outcome. In patients with PE and right ventricular dysfunction (RVD), in hospital mortality ranges from 5% to 17%, significantly higher than in patients without RVD. 4,5)

Pulmonary embolism (PE) is a potentially life-threatening condition and the fact that 90% of PE originate from lower limb veins highlights the significance of early detection and treatment of deep vein thrombosis.1) Massive/high risk PE involving circulatory collapse or systemic arterial hypotension is associated with an early mortality rate of approxi- mately 50%, in part from right ventricular (RV) failure.2) Intermediate risk/submassive PE, on the other hand, is defined as PE-related RV dysfunction, troponin and/or B-type natriuretic peptide elevation despite normal arterial pressure.3) Without prompt treatment, patients with intermediate risk PE may progress to the massive category with a potentially fa- tal outcome. In patients with PE and right ventricular dysfunction (RVD), in hospital mortality ranges from 5% to 17%, significantlyhigherthaninpatientswithoutRVD.4,5) (IntHeartJ2016;57: 91-95)

Key words: Right ventricular dysfunction, Circulatory collapse, hypotension