Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization

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Inceman M., Pehlivan U. A., Toyran T., ÖZDEK R., Paydas S.

Cukurova Medical Journal, cilt.48, sa.1, ss.304-305, 2023 (ESCI) identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 48 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.17826/cumj.1220032
  • Dergi Adı: Cukurova Medical Journal
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.304-305
  • Çukurova Üniversitesi Adresli: Evet

Özet

Primary mediastinal large B-cell lymphoma (PMLBCL) is a mature aggressive large B-cell lymphoma of putative thymic B-cell origin arising in the mediastinum, with distinctive clinical, immunophenotypic, genotypic, and molecular features. Cases that arise outside the mediastinum are very uncommon. A 27-year-old woman presented with mass which had an extramedullary, extradural component at the right T5-6 foramina indenting to the spinal canal, extending craniocaudally from the middle mediastinum to the level of the aortic hiatus. Pathological examination of the mass revealed atypical lymphoid cells with medium-large size, eosinophilic and clear cytoplasm In our case CD23 and MAL expression with morphological findings supported PMLBCL. PMLBCL may be seen with abnormal localization and clinical presentation. Immunohistochemical profile including MAL is helpful to detect these cases.