The study evaluated the influence of Tarantula cubensis extract 1:100/D2 (Theranekron(R), Richter Pharma, Austria) on the treatment of the oral lesions in Bluetongue disease in cattle. Nine Holstein cattle with Bluetongue disease were used in the experiment. Clinical signs included fever, anorexia, acute painful bleeding of oral lesions and lameness. Treatment was started without waiting for the serological confirmation of the disease. Six clinically ill cattle (treatment group) were treated with tetracycline, flunixin meglumin and Tarantula cubensis extract (Theranekron). The remaining three ill cattle were used as control group and treated with the same treatment regiment except for Theranekron. Twenty four hours after theranekron application re-epithelisation occurred and body temperature returned to normal more rapidly in the treatment group than the control group.