The Effects of Trapidil on Fibroblastic Activity, Schwann Cell Proliferation, and Platelet-derived Growth Factor Receptor Levels in the Experimental Sciatic Nerve Injury

ERMAN T., KARA N. N., YILMAZ D. M., GOECER A. I., POLAT S., ZORLUDEMİR S.

NEUROSURGERY QUARTERLY, vol.18, no.4, pp.261-268, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1097/wnq.0b013e3181820aad
  • Journal Name: NEUROSURGERY QUARTERLY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.261-268
  • Çukurova University Affiliated: Yes

Abstract

Background: Trapidil, an antianginal drug with inhibitory effects on platelet-derived growth factor (PDGF), has been shown to reduce reactive fibrosis in models of central nervous system injury. Therefore, we evaluated trapidil's effects on fibroblast activity, Schwann cell proliferation, and PDGF receptor levels in rats after transection and anastomosis of the sciatic nerve. We also evaluated the effect of Schwann cell proliferation on regeneration of anastomosed sciatic nerves.