PREDICTIVE VALUE OF ALDH1 AND CD44 POSITIVITY FOR RADIOTHERAPY RESPONSE AND PROGNOSIS IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA

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SÜRMELİOĞLU Ö., ERDOĞAN K. E., DAĞKIRAN M., ÖZDEMİR S., TARKAN Ö., Uguz A.

POLISH JOURNAL OF PATHOLOGY, cilt.74, sa.1, ss.43-49, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5114/pjp.2022.117177
  • Dergi Adı: POLISH JOURNAL OF PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.43-49
  • Anahtar Kelimeler: laryngeal squamous cell carcinoma, ALDH1, CD44, radiotherapy, CANCER STEM-LIKE, ALDEHYDE DEHYDROGENASE 1, HEAD, MARKER, MANAGEMENT, RADIATION, SURGERY, LASER
  • Çukurova Üniversitesi Adresli: Evet

Özet

To evaluate the predictive value of CD44 and aldehyde dehydrogenase 1 (ALDH1) expression for prognosis and radiotherapy (RT) response in patients with early-stage laryngeal cancer receiving RT. Forty-four patients with early-stage laryngeal cancer diagnosed between 2002 and 2016 were included in the study. The correlation between RT response and pre-treatment immunohistochemical ALDH1 and CD44 staining was evaluated. In addition, survival times were compared between groups. The mean age of the 44 patients was 59.8 +/- 9.0 (43-81) years and 41 were male. There were 20 patients in the non-recurrent group (all men) and 24 patients in the recurrent group (21 men). Immunohistochemical positivity for ALDH1 was found to be a significant risk factor for RT failure (p = 0.0001), whereas CD44 positivity (p = 0.114) and age group (p = 0.287) were not significant. ALDH1 positivity was identified as a significant predictor of DFS and RT sensitivity, while CD44 positivity did not differ according to RT response.