Carotid–femoral pulse wave velocity is significantly increased in newly diagnosed hypertensive patients with primary hyperparathyroidism and significantly related with serum calcium level

BÜYÜKŞİMŞEK M., GULUMSEK E., DEMİRTAŞ D., İÇEN Y. K., SÜMBÜL H. E., OĞUL A., ...Daha Fazla

Journal of Ultrasound, cilt.24, ss.439-446, 2021 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s40477-020-00512-4
  • Dergi Adı: Journal of Ultrasound
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.439-446
  • Anahtar Kelimeler: Primary hyperparathyroidism, Hypertension, Hypercalcaemia, Carotid-femoral pulse wave velocity, LEFT-VENTRICULAR HYPERTROPHY, CARDIOVASCULAR RISK-FACTORS, INTIMA-MEDIA THICKNESS, DISEASE, PARATHYROIDECTOMY, STIFFNESS
  • Çukurova Üniversitesi Adresli: Evet

Özet

Background Primary hyperparathyroidism (PHP) is a rare cause of secondary hypertension (HT), but in patients with PHP, HT is very common and 20-80% of patients have HT. The aim of this study was to evaluate the change in carotid-femoral pulse wave velocity (CF-PWV) in hypertensive patients with PHP, and was to determine the clinical, laboratory, and echocardiographic parameters associated with CF-PWV. Methods The study included 83 newly diagnosed hypertensive patients with PHP and 83 patients with newly diagnosed essential HT without PHP. All patients underwent echocardiography and CF-PWV measurements. Results In patients with PHP, blood urea nitrogen, hs-CRP, uric acid, serum and urine calcium, parathyroid hormone level, CF-PWV value, LV wall thickness, LVMI, aortic and left atrium (LA) diameter, and presence of LVH and CF-PWV > 10 m/s were higher, and serum phosphorus levels were lower. Serum calcium, LA diameter, and LVMI values were closely correlated with CF-PWV. In the ROC analysis, the AUROC was calculated as 0.825 for calcium level to determine the patients with increased CF-PWV. When the serum calcium value was taken as 10 mg/dL, it was determined with CF-PWV > 10 m/s were 79.5% sensitivity and 78.2% specificity. Conclusion CF-PWV significantly increases in newly diagnosed hypertensive patients with PHP and significantly related to serum calcium level. To protect against target organ damage, high serum calcium levels should be monitored as well as blood pressure in hypertensive patients with PHP.