Review and Recommendations on Management of Adult Female Thalassemia Patients with Hypogonadism based on Literature Review and Experience of ICET-A Network Specialists


De Sanctis V., Soliman A. T. , Elsedfy H., Albu A., Al Jaouni S., Anastasi S., ...Daha Fazla

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, cilt.9, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 9
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4084/mjhid.2017.001
  • Dergi Adı: MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES

Özet

Background: Multi-transfused thalassemia major (TM) patients frequently develop severe endocrine complications, mainly due to iron overload, anemia, and chronic liver disease, which require prompt diagnosis, treatment and follow-up by specialists. The most common endocrine complication documented is hypogonadotropic hypogonadism which increases with age and associated comorbidities. It is thus important for physicians to have a clear understanding of the pathophysiology and management of this disorder. Also to be aware of the side effects, contraindications and monitoring of sex steroid therapy. In this paper, practical ICET-A recommendations for the management of hypogonadism in adult females with TM are addressed.