Tc-99M tetrofosmin scintigraphy in acute leukaemia: the relationship between marrow uptake of tetrofosmin and P-glycoprotein and chemotherapy response


Sükan A., Yapar Z., Sahin B. , Kara O., Yapar A., Çetiner S. , et al.

NUCLEAR MEDICINE COMMUNICATIONS, cilt.25, ss.777-785, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background The non-invasive detection of P-glycoprotein (Pgp) and multidrug resistance related proteins in vivo, will represent the greatest challenge in overcoming multidrug resistance. Although Tc-99m tetrofosmin has been used previously as a myocardial perfusion agent, it is now also being used in the imaging of various tumours. In the current study, Tc-99m tetrofosmin was used in the investigation of acute leukaemia.