Green synthesis of 2-amino-3-cyanopyridines via a cooperative vinylogous anomeric-based oxidation and their antiproliferative effects on liver, breast, and prostate cancer studies

ERŞATIR M., Yildirim M.

SYNTHETIC COMMUNICATIONS, cilt.51, sa.8, ss.1252-1265, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 8
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/00397911.2021.1878537
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, EMBASE
  • Sayfa Sayıları: ss.1252-1265
  • Anahtar Kelimeler: Aminocyanopyridine, ultrasonic irradiation, multicomponent reaction, heterocycles, anticancer activity, prostate cancer, breast cancer, liver cancer
  • Çukurova Üniversitesi Adresli: Evet

Özet

2-Amino-3-cyanopyridine derivatives were synthesized in an ultrasonic bath and one pot four-component reactions with high yields, in a short time, without solvent and catalyst, and anticancer activity studies on MCF7, DU145, and HepG2 cell lines were investigated. 18 compounds were synthesized in 4-25 min time interval and 85-99% yield. Among these compounds, the IC50 values in 7a, 6a, and 3a on MCF7 breast cancer cell line was found to be 1.80, 1.95, and 2.50 mu M, respectively, while the values in the HepG2 liver cancer cell line were 7.71, 7.90, and 8.05 mu M, respectively. In studies conducted in the DU145 prostate cancer cell line, IC50 values of compounds 1b, 2b, and 8b were found to be 9.90, 10.10, and 15.30 mu M, respectively.