The effects of the modernization movement, which initiated with the Early Republican Period, began to be monitor in Gaziantep city in the 1950s. In this period, the modern life started to be reflected in the housing space, and the traditional houses were being replaced with the houses which were designed with a modernist approach. In this context, the study focuses on the changes of the housing space, based on the assumptions that housing is the reflection of social life and the changing dynamics of the society affects the formation of the housing space. The changes of spatial configuration of the Gaziantep urban houses constructed between the years 1960 to 1980 were analyzed to determine the effects of socio-cultural and socio-economic changes on the housing culture and the housing formation. It was also aimed to determine how the traditional and modern elements of lifestyle effect the plan features and spatial configuration of the residential space. Space syntax analysis techniques were used to analyze and determine the changes in residential space configuration. The achieved results pointed out that traditional elements effect the formation of the modern housing scheme, the configuration of the housing space has changed over time, and social and cultural factors have an impact on the change.