Objectives: In painful operations like invasive procedures, it is aimed to analyze the effect of making the new-born listen to white noise CD by using the NIPS pain scale. Methods: This is a randomized control trial of research made on 60 new-borns, ranging from 0-28 day-old, 28 gestational weeks and over, and coming to the intensive care unit in Gaziantep Cengiz Gokcek Maternity and Children Hospital in Turkey. New-borns in the experimental group on invasive procedures were exposed to white noise CD. New-borns were recorded while they were listening to white noise during an invasive procedure. Then, the NIPS pain scale on the questionnaire form and efficiency of white noise have been evaluated by comparing the new-borns' duration of crying. Results: New-borns' duration of crying has been found statistically significant in the Independent Samples T-test (p < .05) which was performed between two independent groups with a 95% confidence interval. Duration of crying in the group being exposed to white noise (18.20 sec) has been determined lower than that of the control group (44.96 sec). Conclusion: In the end, the use of white noise CD on new-born during the invasive procedure has been determined to be applicable.