Lack of effect of N-omega-nitro-L-arginine methyl ester on bromocriptine-induced locomotor sensitization in mice

Kayir H., Ceyhan M., Yavuz O., Uzbay I. T.

SYNAPSE, vol.61, no.10, pp.869-874, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1002/syn.20440
  • Journal Name: SYNAPSE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.869-874
  • Keywords: bromocriptine, nitric oxide, L-NAME, locomotor sensitization, mice, OXIDE SYNTHASE, BEHAVIORAL SENSITIZATION, L-NAME, NONASSOCIATIVE SENSITIZATION, ETHANOL WITHDRAWAL, NMDA RECEPTORS, EXPRESSION, RATS, AMPHETAMINE, INHIBITION
  • Çukurova University Affiliated: No

Abstract

The present study was designed to investigate the effects of N-omega-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitory agent, on bromocriptine-induced locomotor sensitization in mice. Adult male Swiss-Webster mice (26-32 g) were the subjects. Saline or L-NAME (15-60 mg/kg) was injected to mice intraperitoneally 30 min before bromocriptine (5 mg/kg), and locomotor activity was recorded for 240 min in an open field activity monitoring system. This procedure lasted for 2 weeks, once in 2 days from Monday to Friday, six sessions in total. After a 2-day drug-free period, a challenge injection of bromocriptine (5 mg/kg) or vehicle was administered by all groups of mice. Other groups of mice treated with bromocriptine according to the aforementioned procedure except L-NAME pretreatments were challenged with saline or L-NAME (15-60 mg/kg) plus bromocriptine (5 mg/kg) after a 2-day drug-free period. Bromocriptine produced a significant locomotor sensitization. L-NAME (15-60 mg/kg) did not have any significant effect on the development and expression of bromocriptine-induced locomotor sensitization in mice. Meanwhile, the data also imply that NO-related mechanisms may not be responsible for bromocriptine-induced locomotor sensitization in mice. Synapse 61:869-874,2007. (C) 2007 Wiley-Liss, Inc.