Progress in Organ Bioprinting for Regenerative Medicine

Wang X., Zhang D., Singh Y. P., Yeo M., Deng G., Lai J., ...More

Engineering, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Publication Date: 2024
  • Doi Number: 10.1016/j.eng.2024.04.023
  • Journal Name: Engineering
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: 3D bioprinting, Organ printing, Regenerative medicine, Tissue engineering
  • Çukurova University Affiliated: No

Abstract

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body's limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The 3D bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas, highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.