Growth hormone and insulin-like growth factor 1 levels and their relation to survival in children with bacterial sepsis and septic shock


Onenli-Mungan N., Yildizdas D. , Yapicioglu H., Topaloglu A. , Yuksel B., Ozer G.

JOURNAL OF PAEDIATRICS AND CHILD HEALTH, cilt.40, ss.221-226, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 40 Konu: 4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1440-1754.2004.00342.x
  • Dergi Adı: JOURNAL OF PAEDIATRICS AND CHILD HEALTH
  • Sayfa Sayısı: ss.221-226

Özet

Objectives: Despite improved supportive care, the mortality of sepsis and septic shock is still high. Multiple changes in the neuroendocrine systems, at least in part, are responsible for the high morbidity and mortality. A reduced circulating level of insulin-like growth factor and an elevated level of growth hormone are the reported characteristic findings early in the course of sepsis and septic shock in adults. The aim of this study was to evaluate the changes of growth hormone/insulin-like growth factor 1 axis in sepsis and septic shock and investigate the relationship between these hormones and survival.