Tumor necrosis factor alpha and interleukin-1 beta levels in cerebrospinal fluid examination for the diagnosis of ventriculoperitoneal shunt-related ventriculitis

OLGUNER, Semih; BOYAR, BÜLENT; ALABAZ, DERYA; ERMAN, TAHSİN; Oktay, KADİR; ARSLAN, Ali; BILGIN, Emre; OKTEN, Ali

doi:10.1007/s00381-019-04070-x

Tumor necrosis factor alpha and interleukin-1 beta levels in cerebrospinal fluid examination for the diagnosis of ventriculoperitoneal shunt-related ventriculitis

OLGUNER S. K., BOYAR B., ALABAZ D., ERMAN T., Oktay K., ARSLAN A., ...Daha Fazla

CHILDS NERVOUS SYSTEM, cilt.35, sa.4, ss.629-636, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 35 Sayı: 4
Basım Tarihi: 2019
Doi Numarası: 10.1007/s00381-019-04070-x
Dergi Adı: CHILDS NERVOUS SYSTEM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.629-636
Anahtar Kelimeler: Shunt infections, Ventriculitis, TNF-alpha, IL-1 beta, TNF-ALPHA, ASEPTIC-MENINGITIS, BACTERIAL-MENINGITIS, CHILDREN, BIOMARKERS, CYTOKINES, IL-6, INFLAMMATION, MALFUNCTION, INFECTIONS
Çukurova Üniversitesi Adresli: Evet

Özet

Purpose Ventriculitis is known to develop after chronic inflammation and bacterial invasion of the ventricular surface with a recurrence of shunt infections. The aim of this study is to evaluate the diagnostic value of elevation in cerebrospinal fluid (CSF) interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) together with CSF culture and laboratory test results in the diagnosis of ventriculoperitoneal (VP) shunt-related ventriculitis, which is known to be more problematic than conventional shunt infection.