Tumor necrosis factor alpha and interleukin-1 beta levels in cerebrospinal fluid examination for the diagnosis of ventriculoperitoneal shunt-related ventriculitis

OLGUNER, Semih; BOYAR, BÜLENT; ALABAZ, DERYA; ERMAN, TAHSİN; Oktay, KADİR; ARSLAN, Ali; BILGIN, Emre; OKTEN, Ali

doi:10.1007/s00381-019-04070-x

Tumor necrosis factor alpha and interleukin-1 beta levels in cerebrospinal fluid examination for the diagnosis of ventriculoperitoneal shunt-related ventriculitis

OLGUNER S. K. , BOYAR B. , ALABAZ D. , ERMAN T. , Oktay K. , ARSLAN A., ...More

CHILDS NERVOUS SYSTEM, vol.35, no.4, pp.629-636, 2019 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 35 Issue: 4
Publication Date: 2019
Doi Number: 10.1007/s00381-019-04070-x
Title of Journal : CHILDS NERVOUS SYSTEM
Page Numbers: pp.629-636
Keywords: Shunt infections, Ventriculitis, TNF-alpha, IL-1 beta, TNF-ALPHA, ASEPTIC-MENINGITIS, BACTERIAL-MENINGITIS, CHILDREN, BIOMARKERS, CYTOKINES, IL-6, INFLAMMATION, MALFUNCTION, INFECTIONS

Abstract

Purpose Ventriculitis is known to develop after chronic inflammation and bacterial invasion of the ventricular surface with a recurrence of shunt infections. The aim of this study is to evaluate the diagnostic value of elevation in cerebrospinal fluid (CSF) interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) together with CSF culture and laboratory test results in the diagnosis of ventriculoperitoneal (VP) shunt-related ventriculitis, which is known to be more problematic than conventional shunt infection.