Unveiling the Impact of Lactic Acid Bacteria on Blood Lipid Regulation for Cardiovascular Health


YILMAZ B., Arslan N., Şahin T. Ö., Ağadündüz D., ÖZOĞUL F., Rocha J. M. F.

Fermentation, cilt.10, sa.7, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 10 Sayı: 7
  • Basım Tarihi: 2024
  • Doi Numarası: 10.3390/fermentation10070350
  • Dergi Adı: Fermentation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: blood lipids, cardiovascular health, fermented food, lactic acid bacteria, lipid metabolism
  • Çukurova Üniversitesi Adresli: Evet

Özet

Lactic acid bacteria (LAB) are a group of microorganisms which are beneficial and well-characterized with respect to the flavor and texture of food products via fermentation. The accumulated literature has suggested that dietary intake of fermented foods rich in LAB is related to different health-promoting benefits; however, in recent years, emerging evidence suggests a contribution of LAB to blood lipid regulation and cardiovascular health via certain mechanisms. Different potential mechanisms for the lipid regulatory effects of LAB may include the interaction of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and bile salt hydrolase activity and bile salt metabolism; gut microbiome modulation; and regulation of mRNA expression of genes related to fat metabolism in animal models and human studies. This review comprehensively aims to answer whether/how LAB influence blood lipids in both animal models and human studies while also uncovering the underlying mechanisms linking LAB to lipid metabolism.