Vasculitis associated with all trans retinoic acid (ATRA) in a case with acute promyelocytic leukemia

Paydas S., Yavuz S., Disel U., Sahin B., Canbolat T., Tuncer İ.

LEUKEMIA & LYMPHOMA, cilt.44, sa.3, ss.547-548, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1080/1042819021000055101
  • Dergi Adı: LEUKEMIA & LYMPHOMA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.547-548
  • Anahtar Kelimeler: vasculitis, ATRA, all trans-retinoic acid, APL, acute promyelocytic leukemia, Sweet's syndrome, SWEETS-SYNDROME, PATIENT, THERAPY
  • Çukurova Üniversitesi Adresli: Evet

Özet

All trans retinoic acid is the drug of choice in the treatment of acute promyelocytic leukemia. But this drug has some side effects, some of which may be life-threatening. Retinoic acid syndrome is the most frequent and dangerous side effect of this differentiation inducing agent. Other side effects include Sweet's syndrome, vasculitis, hypercalcemia, bone marrow necrosis and fibrosis, thromboembolic events, erythema nodosum, granulomatous proliferation and some pulmonary complications. Here, we report vasculitis in a case with APL treated with ATRA and review the literature.