A RANDOMIZED TRIAL OF 2 CISPLATIN-CONTAINING CHEMOTHERAPY REGIMENS IN PATIENTS WITH STAGE-III-B AND STAGE-IV NONSMALL CELL LUNG-CANCER


ERKISI M., DORAN F., BURGUT R., KOCABAS A.

LUNG CANCER, cilt.12, ss.237-246, 1995 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 12 Konu: 3
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0169-5002(95)00447-9
  • Dergi Adı: LUNG CANCER
  • Sayfa Sayısı: ss.237-246

Özet

Seventy-four newly diagnosed patients with histologically proven Stage III-B and IV non-small cell lung cancer were randomized to receive either cisplatin: 20 mg/m(2) x day x 5, ifosfamide: 1.8 g/m(2) x day x 5, mesna: 1.2 g/m(2) x day x 5, etoposide: 100 mg/m(2) x day x 5 (ICE) or cisplatin: 20 g/m(2) x day x 5 and etoposide: 100 mg/m(2) x day x 5. Response rates were 59% in the ICE and 40% in the CE arm with a significant advantage in response duration and overall survival in the ICE receiving patients (P = 0.03, P = 0.0008). As we used granulocyte colony stimulating factor (G-CSF) very frequently, myelotoxicity remained substantial but acceptable.