Polysaccharides to Combat Viruses (COVID-19) and Microbes: New updates

AlMatar M., Makky E. A., Ramli A. N. M., YAŞA KAFKAS N. E., KÖKSAL F.

CURRENT MOLECULAR PHARMACOLOGY, cilt.15, sa.6, ss.803-814, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.2174/1874467215666220112150332
  • Dergi Adı: CURRENT MOLECULAR PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.803-814
  • Anahtar Kelimeler: Polysaccharides, Covid-19, microbes, biofilm, antiviral activity, natural sources, HEPARAN-SULFATE PROTEOGLYCANS, HUMAN-MILK OLIGOSACCHARIDES, HEPATITIS-A VIRUS, ANTIVIRAL ACTIVITY, ASTRAGALUS POLYSACCHARIDES, MOLECULAR-WEIGHT, STRUCTURAL-CHARACTERIZATION, BIOACTIVE POLYSACCHARIDES, CARBOXYMETHYL CHITOSAN, ANTIMICROBIAL ACTIVITY
  • Çukurova Üniversitesi Adresli: Evet

Özet

COVID-19, which is speedily distributed across the world and presents a significant challenge to public health, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Following MERS coronavirus (MERS-CoV) and SARS, this is the third severe coronavirus outbreak in less than 20 years. To date, there are no exact agents and vaccines available for the treatment of COVID-19 that are clinically successful. Antimicrobial medications are effective in controlling infectious diseases. However, the extensive use of antibiotics makes microbes more resistant to drugs and demands novel bioactive agents' development. Polysaccharides are currently commonly used in the biomedical and pharmaceutical industries for their remarkable applications. Polysaccharides appear to have a wide range of anti-virus (anti-coronavirus) and antimicrobial applications. Polysaccharides are able to induce bacterial cell membrane disruption as they demonstrate potency in binding onto the surfaces of microbial cells. Here, the antiviral mechanisms of such polysaccharides and their success in the application of antiviral infections are reviewed. Additionally, this report provides a summary of current advancements of well-recognized polysaccharides as antimicrobial and anti-biofilm agents.