THE BETA-THALASSEMIA MUTATIONS IN THE POPULATION OF CYPRUS


BAYSAL E., INDRAK K., BOZKURT G., BERKALP A., ARITKAN E., OLD J., ...Daha Fazla

BRITISH JOURNAL OF HAEMATOLOGY, cilt.81, sa.4, ss.607-609, 1992 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 81 Sayı: 4
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1111/j.1365-2141.1992.tb03000.x
  • Dergi Adı: BRITISH JOURNAL OF HAEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.607-609
  • Çukurova Üniversitesi Adresli: Hayır

Özet

We have identified the beta-thalassaemia alleles in nearly all known Turkish Cypriot beta-thalassaemia homozygotes and in over 700 Greek Cypriot beta-thalassaemia heterozygotes living on the island of Cyprus. The data confirmed earlier observations that the IVS-I-100 (G-->A) mutation is present for about 74-80%, while three other alleles [IVS-II-745 (C-->G), IVS-1-6 (T-->C), IVS-I-1 (G-->A)] occur at frequencies of 5-8%. Nearly identical percentages were observed for the two Cypriot groups, quite different from those for beta-thalassaemia patients from Greece and Turkey. This suggests close contacts between the two Cypriot communities during many centuries without a major recent influence from Greek or Turkish beta-thalassaemia carriers.