Exercise for improving bone health in patients with AIRDs: Understanding underlying biology and physiology


COŞKUN BENLİDAYI İ., Gupta L., Parihar J., Levy A. L., Alexanderson H.

International Journal of Rheumatic Diseases, vol.27, no.11, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 27 Issue: 11
  • Publication Date: 2024
  • Doi Number: 10.1111/1756-185x.15402
  • Journal Name: International Journal of Rheumatic Diseases
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Keywords: bone and bones, bone mineral density, exercise, osteoporosis, rheumatic diseases
  • Çukurova University Affiliated: Yes

Abstract

Exercise has numerous health benefits in patients with autoimmune inflammatory rheumatic diseases (AIRDs). Regular physical activity can help maintain/improve bone health. The aim of the present article was to review current knowledge on the effects of exercise on bone health in patients with AIRDs, particularly in those experiencing a high corticosteroid burden. The article also aimed to discuss potential mechanisms underlying the benefits of physical activity/exercise on bone tissue. Potential explanations regarding the role of exercise on bone health in AIRDs include anti-inflammatory effects, mechanical loading, improvement in muscle strength, hormonal changes, improvement in balance, and effects on telomere erosion, deoxyribonucleic acid methylation, and gene expression. Current evidence regarding the outcomes of exercise on bone health in patients with AIRDs is predominantly derived from studies focused on rheumatoid arthritis. Expanding research to include other rheumatic conditions would enhance the overall understanding of this topic.