Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients

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Aikimbaev K., Güney İ. B., Pişkin F. C.

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY, vol.1, no.1, pp.1-5, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 1 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.4274/dir.2021.211255
  • Journal Name: DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-5
  • Çukurova University Affiliated: Yes

Abstract

PURPOSE

To analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttri- um-90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients.

METHODS

Interleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor, vascular endothelial growth factor-A (VEGF-A), and angiopoietin-2 levels in 26 pa- tients were measured before TARE and on day 1, 7, 14, and 30 after TARE and evaluated regarding radiological response.

RESULTS

In the sixth month of follow-up, 11 (42.30%) patients had a complete or partial response to treat- ment, while progressive disease was found in 15 (57.69%) patients. The percentage changes in VEGF-A in the non-responders on day 30 (P = 0.034) after TARE were significantly more obvious. Peak formation rates of VEGF-A were higher in non-responders (P = 0.036).

CONCLUSION

Short-term changes in angiogenesis factors in HCC patients after TARE with Yttrium-90-loaded resin microspheres fluctuate with different amplitudes at different times. The upregulation of growth factors has a prognostic capacity. Changes in VEGF-A after TARE may be helpful for the early recog- nition of non-responders.