Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients

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Aikimbaev K., Güney İ. B., Pişkin F. C.

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY, cilt.1, sa.1, ss.1-5, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.4274/dir.2021.211255
  • Dergi Adı: DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-5
  • Çukurova Üniversitesi Adresli: Evet

Özet

PURPOSE

To analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttri- um-90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients.

METHODS

Interleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor, vascular endothelial growth factor-A (VEGF-A), and angiopoietin-2 levels in 26 pa- tients were measured before TARE and on day 1, 7, 14, and 30 after TARE and evaluated regarding radiological response.

RESULTS

In the sixth month of follow-up, 11 (42.30%) patients had a complete or partial response to treat- ment, while progressive disease was found in 15 (57.69%) patients. The percentage changes in VEGF-A in the non-responders on day 30 (P = 0.034) after TARE were significantly more obvious. Peak formation rates of VEGF-A were higher in non-responders (P = 0.036).

CONCLUSION

Short-term changes in angiogenesis factors in HCC patients after TARE with Yttrium-90-loaded resin microspheres fluctuate with different amplitudes at different times. The upregulation of growth factors has a prognostic capacity. Changes in VEGF-A after TARE may be helpful for the early recog- nition of non-responders.