DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY, cilt.1, sa.1, ss.1-5, 2023 (SCI-Expanded)
PURPOSE
To analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttri- um-90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients.
METHODS
Interleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor, vascular endothelial growth factor-A (VEGF-A), and angiopoietin-2 levels in 26 pa- tients were measured before TARE and on day 1, 7, 14, and 30 after TARE and evaluated regarding radiological response.
RESULTS
In the sixth month of follow-up, 11 (42.30%) patients had a complete or partial response to treat- ment, while progressive disease was found in 15 (57.69%) patients. The percentage changes in VEGF-A in the non-responders on day 30 (P = 0.034) after TARE were significantly more obvious. Peak formation rates of VEGF-A were higher in non-responders (P = 0.036).
CONCLUSION
Short-term changes in angiogenesis factors in HCC patients after TARE with Yttrium-90-loaded resin microspheres fluctuate with different amplitudes at different times. The upregulation of growth factors has a prognostic capacity. Changes in VEGF-A after TARE may be helpful for the early recog- nition of non-responders.