Ischemia-Reperfusion Injury of Sciatic Nerve in Rats and Protective Role of Benidipine Hydrochloride

ÇAKIR T., Yucetas S. C., YAZICI G. N., SUNAR M., Arslan Y. K., KAYACI S., ...More

EUROPEAN JOURNAL OF THERAPEUTICS, vol.27, no.4, pp.286-292, 2021 (ESCI, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.5152/eurjther.2021.21031
  • Journal Name: EUROPEAN JOURNAL OF THERAPEUTICS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.286-292
  • Keywords: ischemia-reperfusion, sciatic nerve, benidipine hydrochloride, CALCIUM-CHANNEL BLOCKER, OXIDATIVE STRESS, LIPID-PEROXIDATION, SUPEROXIDE-DISMUTASE, THIOBARBITURIC ACID, PERIPHERAL-NERVE, NEUROPROTECTION, GLUTATHIONE, DISEASES, TISSUE
  • Çukurova University Affiliated: No

Abstract

Objective: Benidipine is an antihypertansive agent which elicits vasodilatation of arteries by blocking Ca2+. The aim of this study is to investigate the neuroprotective effects of benidipine on rat sciatic nerves exposed to ischemia and reperfusion (I/R).