Akademik Veri Yönetim Sistemi
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.47, sa.4, ss.275-278, 2010 (SCI-Expanded)
Assisted reproductive techniques are used in the treatment of infertility worldwide. Long-term and multidimensional effects of these techniques on the embryo, especially on genetic programming, are still unknown. Moreover, the difficult period before parenting may affect the attachment and, consequently, the child's mental health. The aim of this review is to discuss the neurodevelopmental and behavioral effects of assisted reproductive techniques from fetal and early childhood stages to adolescence. Follow-up studies, case reports, and meta-analyses investigating the neurological, psychiatric and genetic effects of in vitro fertilization techniques were reviewed. Animal studies suggest that the serum content, in which the embryo is preserved, may damage its genetic programming. Cerebral palsy, preterm delivery and low birth weight are the most frequent obstetric complications. Executive functions, memory and attention may be affected, especially in school-age children. Cases of autism have been reported as well. Preimplantation genetic screening has not been commonly used because of its high cost, complex technical procedures and ethical responsibilities. This paper suggests that multidisciplinary approach is needed in order to predict neurological and mental disorders. Parenting education and psychosocial support for infertile couples may facilitate the healthy attachment with their baby. (Archives of Neuropsychiatry 2010; 47: 275-8)