In this work, ZnO nanopowders with different morphology such as nanoleafy and nanosphere were synthesized by hydrothermal method. The X-ray Diffraction (XRD) spectra have showed that ZnO nanopowders synthesized in different morphologies have a highly crystallized hexagonal structure. Scanning Electron Microscopy (SEM) was used to examine the morphology of nanopowders and revealed that they were formed in the nanoleafy and nanosphere structure. Dye-Sensitized Solar Cell (DSSC) fabrication was performed by using ZnO nanopowders as a photoelectrode. The Dye-Sensitized Solar Cells (DSSCs) were immersed in N719 dye at 4h and the performance of the cells (conversion efficiency, open circuit voltage, fill factor and short circuit current) of ZnO-DSSCs were obtained. It has been observed the highest efficiency value of 1.59% for nanosphere ZnO:DSSC.