Pronostic significance of angiogenic/lymphangiogenic, anti-apoptotic, inflammatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the literature

PAYDAŞ S., ERGİN M., SEYDAOĞLU G., ERDOĞAN Ş., Yavuz S.

LEUKEMIA RESEARCH, vol.33, no.12, pp.1627-1635, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 12
  • Publication Date: 2009
  • Doi Number: 10.1016/j.leukres.2009.02.015
  • Journal Name: LEUKEMIA RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1627-1635
  • Keywords: Lymphoma, VEGF-A, VEGF-C, Cox-2, TSP-1, Survivin, EBV, Prognosis, Angiogenesis, Lymphangiogenesis, EPSTEIN-BARR-VIRUS, ENDOTHELIAL GROWTH-FACTOR, NON-HODGKINS-LYMPHOMA, CHRONIC LYMPHOCYTIC-LEUKEMIA, LATENT GENE-EXPRESSION, COLON-CANCER CELLS, N-TERMINAL DOMAIN, PROGNOSTIC-SIGNIFICANCE, VEGF-C, CYCLOOXYGENASE-2 EXPRESSION
  • Çukurova University Affiliated: Yes

Abstract

Background: Diffuse large B cell lymphoma (DLBCL) is the most common subtype of Non-Hodgkins lymphomas (NHL). The outcome of these patients shows a wide variation. We evaluated the effect of six biologic parameters including Cyclooxygenase-2 (Cox-2), Survivin, Epstein Barr Virus (EBV), Vascular Endothelial Growth Factor-A (VEGF-A), Vascular Endothelial Growth Factor-C (VEGF-C), Thrombospondin-1 (TSP-1) and clinical parameters.