Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey

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Izmirli M., Sen B. B., Rifaioglu E., GÖGEBAKAN B., ALDEMİR Ö., Sen T., ...More

ANAIS BRASILEIROS DE DERMATOLOGIA, vol.91, no.5, pp.611-613, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 91 Issue: 5
• Publication Date: 2016
• Doi Number: 10.1590/abd1806-4841.20164766
• Journal Name: ANAIS BRASILEIROS DE DERMATOLOGIA
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.611-613
• Çukurova University Affiliated: No

Abstract

Background: Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR).