Akademik Veri Yönetim Sistemi
Journal of Drug Delivery Science and Technology, cilt.122, 2026 (SCI-Expanded, Scopus)
Burn wound healing is often delayed by prolonged inflammation, insufficient angiogenesis, and impaired extracellular matrix remodeling. Plant-derived bioactive compounds have emerged as promising therapeutic agents; however, their efficient topical delivery remains challenging. In this study, a nanoemulsion formulation containing Lavandula angustifolia essential oil and Pinus brutia extract was developed and evaluated for its burn wound healing potential. The formulations were physicochemically characterized and their cytocompatibility was assessed using NIH/3T3 and L929 fibroblast cell lines. The in vivo wound healing activity was investigated in a burn wound model by evaluating wound contraction, histopathological alterations, and key molecular mediators involved in tissue repair. ELISA analyses were performed to quantify inflammatory cytokines (TNF-α, IL-1β, IL-6), angiogenic growth factors (VEGF, TGF-β), extracellular matrix remodeling markers (MMP-1, TIMP-1), and hydroxyproline levels as an indicator of collagen deposition. The nanoemulsion treatments significantly accelerated wound closure compared with the untreated control group. Particularly, the combined lavender–Pinus nanoemulsion demonstrated enhanced re-epithelialization, improved collagen organization, and increased angiogenic activity. These effects were supported by reduced pro-inflammatory cytokine levels and elevated VEGF, TGF-β, and hydroxyproline levels. Histopathological evaluation further confirmed advanced tissue regeneration in the treated groups. Overall, the results indicate that the Lavandula angustifolia – and Pinus brutia –loaded nanoemulsion promotes burn wound healing through coordinated regulation of inflammation, angiogenesis, and extracellular matrix remodeling, highlighting its potential as a plant-derived therapeutic platform for regenerative wound management.