Investigation of the effects of vitamin D treatment on the ovarian AMH receptors in a polycystic ovary syndrome experimental model: an ultrastructural and immunohistochemical study

Kuyucu Y., Sencar L., Tap Ö., Mete U. Ö.

REPRODUCTIVE BIOLOGY, cilt.20, ss.25-32, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.repbio.2020.01.001
  • Dergi Adı: REPRODUCTIVE BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.25-32
  • Anahtar Kelimeler: AMH, Vitamin D, Immunohistochemistry, Ultrastructure, PCOS, ANTI-MULLERIAN HORMONE, FOLLICULAR DEVELOPMENT, EXPRESSION, FOLLICULOGENESIS, STEROIDOGENESIS, MANAGEMENT, FERTILITY, ETIOLOGY, WOMEN, FSH
  • Çukurova Üniversitesi Adresli: Evet

Özet

The aim of this study was to demonstrate the effects of vitamin D treatment on ultrastructural changes and AMHR2 expression in the ovary in PCOS rat model. A total of 24 female prepubertal rats were divided into 3 groups. In group 1, sesame oil was injected and used as control group. In group 2, PCOS was created by the injection of 6 mg/kg/day DHEA. In group 3, PCOS was created and 120 ng/100 g 1,25 (OH)(2)D3 treatment was performed. At the end of the 28th day, the blood samples were collected. The ovarian tissues were obtained for electron microscopic and immunohistochemical examinations.