Cluster headache is characterized by unilateral severe periorbital hemicranial pain. It is the most frequent form of trigemino-autonomic headaches. Diagnosis is straightforward after a thorough history taking and neurologic examination. Attack treatment and prophylactic therapy should be considered in all cases. Treatment might be challenging particularly in cluster headaches. In this study, treatment period and its results are presented in four cluster headache cases (52, 71, 48 and 28 years old) with drug resistant attacks. One gr of methylprednisolone was administered to all four cases for 3 days accompanied by prophylactic treatment. Attack severity and frequency subsided gradually after the treatment followed by a complete recovery. Remission periods were prolonged. Regarding these cases, we concluded that high dose steroid therapy might be efficient in chronic cluster headaches.