Oxidative and apoptotic effects of lambda-cyhalothrin modulated by piperonyl butoxide in the liver of Oreochromis niloticus

Piner P. , UNER N.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, cilt.33, sa.3, ss.414-420, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.etap.2012.01.001
  • Sayfa Sayıları: ss.414-420


The aim of this study was to investigate the toxic effects of pyrethroid pesticide lambda cyhalothrin in the presence of piperonyl butoxide as a modulator in the liver of juvenile Oreochromis niloticus. LC50 (96 h) value of lambda-cyhalothrin was determined as 2.901 mu g/L for O. niloticus. The fish were exposed to 0.48 mu g/L (116 of the 96-h LC50) lambda-cyhalothrin and 10 mu g/L piperonyl butoxide for 96-h and 15-d. tGSH, GSH, GSSG, Hsp70 and TSARS contents, GPx, GR, GST and caspase-3 enzymes activities were determined. Lambda-cyhalothrin caused increases in tGSH, GSH, TBARS contents, and GST activity. Piperonyl butoxide treatment with lambda-cyhalothrin caused significant increases in tGSH GSH, Hsp70, TBARS contents, and GPx and GST activities while caspase-3 activity was decreased. The results of the present study revealed that lambda-cyhalothrin caused oxidative stress which upregulated GSH and GSH-related enzymes. Piperonyl butoxide increased the oxidative stress potential and apoptotic effects of lambda-cyhalothrin. (C) 2012 Elsevier B.V. All rights reserved.