Neurokinin B Signalling in Human Puberty


TOPALOĞLU A. K. , KOTAN L. D. , YÜKSEL B.

JOURNAL OF NEUROENDOCRINOLOGY, vol.22, no.7, pp.765-770, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 22 Issue: 7
  • Publication Date: 2010
  • Doi Number: 10.1111/j.1365-2826.2010.02013.x
  • Title of Journal : JOURNAL OF NEUROENDOCRINOLOGY
  • Page Numbers: pp.765-770

Abstract

Recent identification of TAC3 or TACR3 (encoding neurokinin B and its receptor, NK3R, respectively) mutations as the causes of normosmic idiopathic hypogonadotrophic hypogonadism has provided compelling evidence for the involvement of neurokinin B (NKB) signalling in puberty. A surge of subsequent studies pointing towards an understanding of the exact mechanism through which NKB signalling exerts its effects in puberty led to a postulated sketch of the GnRH pulse generator, in which kisspeptin, NKB and dynorphin work in concert to elicit pulsatile gonadotrophin-releasing hormone release in the median eminence.