TETRAHEDRON, vol.57, no.32, pp.7035-7045, 2001 (SCI-Expanded)
Electrophile induced cyclisation of oximes onto endocyclic alkenes and exo-methylene cycloalkanes occurs stereo- and regiospecifically generating cis-fused bicyclic nitrones in good yield. Subsequent facially selective cycloaddition with N-methylmaleimide occurs in good yield. The sequence may be carried out as a one-pot procedure and results in the formation of 4 bonds, 2 rings and 6 stereocentres. (C) 2001 Elsevier Science Ltd. All rights reserved.