Synthesis of some novel tricyclic alpha-aminoacid esters and potential bioactive compounds via 1,2-prototropy and 1,3-APT cascade reactions

Dondas H. A., Dondas N.

HETEROCYCLIC COMMUNICATIONS, vol.10, pp.313-318, 2004 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2004
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.313-318
  • Çukurova University Affiliated: No


Some novel cyclic alpha-aminoacid esters and potential bioactive compounds were prepared via thermal 1,2-prototropy- and 1,3-APT oxime nitrone-1,3-dipolar cycloaddition cascades reactions. This substrate allows the influence of the new stereocentres on the cascade to be assessed with respect to the configuration of the nitrone that is generated and the facial selectivity of the subsequent cycloaddition.