Synthesis of some novel tricyclic alpha-aminoacid esters and potential bioactive compounds via 1,2-prototropy and 1,3-APT cascade reactions


Dondas H. A. , Dondas N.

HETEROCYCLIC COMMUNICATIONS, vol.10, pp.313-318, 2004 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2004
  • Title of Journal : HETEROCYCLIC COMMUNICATIONS
  • Page Numbers: pp.313-318

Abstract

Some novel cyclic alpha-aminoacid esters and potential bioactive compounds were prepared via thermal 1,2-prototropy- and 1,3-APT oxime nitrone-1,3-dipolar cycloaddition cascades reactions. This substrate allows the influence of the new stereocentres on the cascade to be assessed with respect to the configuration of the nitrone that is generated and the facial selectivity of the subsequent cycloaddition.