MANNOSE BINDING LECTIN (MBL) GENE POLYMORPHISMS AND THEIR RELATIONS WITH CLINICAL FEATURES IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER (FMF)

ERKEN, ERTUĞRUL; Kudas, Ozlem; DİNKÇİ, SUZAN; Kuyucu, Yunus; TAŞLIYURT, TÜRKER; ERKEN, EREN

MANNOSE BINDING LECTIN (MBL) GENE POLYMORPHISMS AND THEIR RELATIONS WITH CLINICAL FEATURES IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER (FMF)

Atıf İçin Kopyala

ERKEN E., Kudas O., DİNKÇİ S., Kuyucu Y. E., TAŞLIYURT T., ERKEN E.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.80, sa.4, ss.125-130, 2017 (ESCI)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 80 Sayı: 4
Basım Tarihi: 2017
Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.125-130
Çukurova Üniversitesi Adresli: Evet

Özet

Objective: Mannose-binding lectin (MBL), which takes part in the lectin pathway of the complement system as a component of innate immunity, is activated by the stimulation of various bacterial lectins. It is known that some of the MBL gene polymorphisms (eg, codon 52, codon 54) that may lead to alterations in MBL serum levels are responsible for the susceptibility to infectious diseases and contribute to the pathogenesis of various autoimmune and inflammatory diseases. In this study, we planned to investigate the frequencies of codon 52 and codon 54 polymorphisms of the MBL gene in FMF patients and their association with the clinical features of the disease.