MANNOSE BINDING LECTIN (MBL) GENE POLYMORPHISMS AND THEIR RELATIONS WITH CLINICAL FEATURES IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER (FMF)


ERKEN E., Kudas O., DİNKÇİ S. , Kuyucu Y. E. , TAŞLIYURT T., ERKEN E.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.80, no.4, pp.125-130, 2017 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 4
  • Publication Date: 2017
  • Title of Journal : JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Page Numbers: pp.125-130

Abstract

Objective: Mannose-binding lectin (MBL), which takes part in the lectin pathway of the complement system as a component of innate immunity, is activated by the stimulation of various bacterial lectins. It is known that some of the MBL gene polymorphisms (eg, codon 52, codon 54) that may lead to alterations in MBL serum levels are responsible for the susceptibility to infectious diseases and contribute to the pathogenesis of various autoimmune and inflammatory diseases. In this study, we planned to investigate the frequencies of codon 52 and codon 54 polymorphisms of the MBL gene in FMF patients and their association with the clinical features of the disease.