Objective: To present a case with nephrotic syndrome due to minimal change disease and polycythemia. Clinical Presentation and Intervention: A 20-year-old female was admitted to our clinic for edema and severe proteinuria present with minimal change disease since the age of 7 years. Polycythemia was found during the last activation of nephrotic syndrome. The patient was placed on glucocorticoid therapy that caused disappearance of edema, proteinuria and polycythemia. Ten months later both hemoglobin and hematocrit levels were within normal range. Conclusion: This patient with nephrotic syndrome due to minimal change disease and polycythemia was successfully treated with glucocorticoid. Copyright (C) 2004 S. Karger AG, Basel.