Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors


YAMALI C. , GÜL H. İ. , Çakır T., Demir Y., GÜLÇİN İ.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.17, no.10, pp.1283-1292, 2020 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.2174/1570180817999200520123510
  • Title of Journal : LETTERS IN DRUG DESIGN & DISCOVERY
  • Page Numbers: pp.1283-1292
  • Keywords: Mannich, chalcone, carbonic anhydrases, acetylcholinesterase, phenol, hCA I, hCA II, MANNICH BASE DERIVATIVES, MULTIFUNCTIONAL AGENTS, HCA IX, BIOACTIVITIES, CYTOTOXICITY, APOPTOSIS, DESIGN

Abstract

Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE) inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are molecular targets for anticonvulsant, diuretic and antiglaucoma drugs in the clinic. Phenolic compounds have also been mentioned as CA inhibitors. The importance of Mannich bases in drug design inspired our research group to design novel phenolic Mannic bases as potent enzyme inhibitors.