LETTERS IN DRUG DESIGN & DISCOVERY, vol.17, no.10, pp.1283-1292, 2020 (Journal Indexed in SCI)
Article / Article
Title of Journal :
LETTERS IN DRUG DESIGN & DISCOVERY
Mannich, chalcone, carbonic anhydrases, acetylcholinesterase, phenol, hCA I, hCA II, MANNICH BASE DERIVATIVES, MULTIFUNCTIONAL AGENTS, HCA IX, BIOACTIVITIES, CYTOTOXICITY, APOPTOSIS, DESIGN
Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE) inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are molecular targets for anticonvulsant, diuretic and antiglaucoma drugs in the clinic. Phenolic compounds have also been mentioned as CA inhibitors. The importance of Mannich bases in drug design inspired our research group to design novel phenolic Mannic bases as potent enzyme inhibitors.