Does prophylactic ondansetron reduce norepinephrine consumption in patients undergoing cesarean section with spinal anesthesia?

KARACAER F., BİRİCİK E., ÜNAL İ., BÜYÜKKURT S., ÜNLÜGENÇ H.

JOURNAL OF ANESTHESIA, vol.32, no.1, pp.90-97, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1007/s00540-017-2436-x
  • Journal Name: JOURNAL OF ANESTHESIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.90-97
  • Çukurova University Affiliated: Yes

Abstract

Spinal anesthesia-induced hypotension (SAIH) during cesarean delivery is not rare and frequently leads to materno-fetal discrepancy and collapse. More recently, norepinephrine has been proposed for the prevention and treatment of SAIH with fewer tendencies to decrease heart rate and cardiac output. Ondansetron has been reported to reduce the incidence of SAIH in patients undergoing cesarean section. The aim of the present study was to assess the effect of prophylactic ondansetron on the incidence of SAIH, norepinephrine consumption, and adverse effects.