Assessment of chromosomal aberration in the bone marrow cells of Swiss Albino mice treated by 4-methylimidazole


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Tazehkand M. N. , TOPAKTAŞ M. , YILMAZ M. B.

DRUG AND CHEMICAL TOXICOLOGY, cilt.39, ss.307-311, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 39 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/01480545.2015.1113989
  • Dergi Adı: DRUG AND CHEMICAL TOXICOLOGY
  • Sayfa Sayıları: ss.307-311

Özet

4-Methylimidazole (4-MEI) is formed during the production of certain caramel coloring agents used in many food and drink products. It may also be formed during the cooking, roasting, or other processing of some foods and beverages. So it was unintentionally consumed in worldwide. This study was aimed to investigate the genotoxic and cytotoxic effects of 4-MEI using chromosome aberration (CA) and mitotic index (MI) in Swiss Albino mice. In this research, CA and MI of the mouse bone marrow cells were analyzed after treating the animals with 4-MEI (100, 130 and 160 mg/kg) for 12 h and 24 h treatment times. All data were analyzed using statistical methods. 4-MEI significantly increased the percentage of CAs at all concentrations for 12 h and at highest concentration for 24 h treatment periods. 4-MEI at highest concentration for 12 h and at all concentrations for 24 h decreased the MI in comparison with control. Genotoxic and cytotoxic effects of 4-MEI at 24 h treatment periods were concentration dependent. Consequently, it can be said that 4-MEI have genotoxic and cytotoxic effect in mouse.

4-Methylimidazole (4-MEI) is formed during the production of certain caramel coloring agents
used in many food and drink products. It may also be formed during the cooking, roasting, or
other processing of some foods and beverages. So it was unintentionally consumed in
worldwide. This study was aimed to investigate the genotoxic and cytotoxic effects of 4-MEI
using chromosome aberration (CA) and mitotic index (MI) in Swiss Albino mice. In this research,
CA and MI of the mouse bone marrow cells were analyzed after treating the animals with 4-MEI
(100, 130 and 160 mg/kg) for 12 h and 24 h treatment times. All data were analyzed using
statistical methods. 4-MEI significantly increased the percentage of CAs at all concentrations
for 12 h and at highest concentration for 24 h treatment periods. 4-MEI at highest
concentration for 12 h and at all concentrations for 24 h decreased the MI in comparison
with control. Genotoxic and cytotoxic effects of 4-MEI at 24 h treatment periods were
concentration dependent. Consequently, it can be said that 4-MEI have genotoxic and cytotoxic
effect in mouse.