Background: Our aim was to compare drain materials with respect to their peritoneal reactions, abdominal infections, wound infections and omental covering. Materials and Methods: Pieces of silicon, plastic, caoutchouc and latex drains were placed in the abdominal cavity of rats. Laparotomies at intervals of 0, 2, and 5 days were performed in each group of animals. Drain infection, wound infection, reactional periteoneal fluid occurrence and omental covering of drain were noted. Results: Similar bacteria species were established in drain and wound cultures. While drain infections were observed mostly in the caoutchouc group on the 2nd day, drain infection was established in each group on the 5th day. Reactional fluid occurrence was observed most frequently in the latex group. The caoutchouc group exhibited the highest degree of omental covering. Conclusion: The placement of unnecessary drains should be avoided. Drains must be removed as early as possible. In surgery, silicon drains should be preferred because of their low complication, obstruction and foreign body reaction rates.