Akademik Veri Yönetim Sistemi
International Journal of Medical Investigation, cilt.13, sa.2, ss.162-176, 2024 (Hakemli Dergi)
Background: Hemoglobinopathies, the most prevalent single-gene disorders worldwide, are
projected to see an increase in prevalence in the future. This study aims to identify abnormal
hemoglobin variants in the Çukurova region.
Methods: Blood samples were collected at the Central Laboratory of Çukurova University Balcalı
Hospital, and abnormal hemoglobin types were determined using hemoglobin electrophoresis,
sickling, and ARMS methods.
Results: The study identified 115 cases of HbAS, 60 cases of HbSS, 3 cases of HbSC, 2 cases of
HbAC, and 1 case of HbAE. The findings indicate that the carriage of sickle cell traits is highest in
the Çukurova region. The objective is to reduce the number of affected births and mitigate the
economic burden on the country by implementing screening programs in regions where
hemoglobinopathy is endemic.
Conclusion: The Çukurova Region's high prevalence of HbS and the common practice of
consanguineous marriages increase the likelihood of babies being born with HbSS. New screening
methods are urgently needed to accurately distinguish carriers from patients and rule out common
conditions like iron deficiency anemia. The success of screening programs depends on the population's
acceptance, which can be improved through awareness creation and effective genetic counseling postdiagnosis.
Keywords: Hemoglobin Variants, Çukurova, Prevalence, Clinical Implications