An Analysis of C-Reactive Protein, Procalcitonin, and D-Dimer in Pre-Eclamptic Patients

GULEC U. K., OZGUNEN F. T., GÜZEL A. B., BÜYÜKKURT S., SEYDAOĞLU G., ÜRÜNSAK İ. F., ...More

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol.68, no.4, pp.331-337, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1111/j.1600-0897.2012.01171.x
  • Journal Name: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.331-337
  • Keywords: C-reactive protein, D-Dimer, Procalcitonin, severe pre-eclampsia, systemic inflammatory response syndrome (SIRS), INFLAMMATORY MARKERS, NORMAL-PREGNANCY, HEMOSTASIS, SEVERITY, SEPSIS, VALUES, WOMEN
  • Çukurova University Affiliated: Yes

Abstract

Problem The aim of this study was to evaluate serum procalcitonin (PCT), C-reactive protein (CRP), and plasma D-Dimer levels in mild and severe pre-eclampsia. Method of study Serum PCT, CRP, and D-Dimer levels were analyzed in 64 cases with pre-eclampsia as the study group and 33 healthy pregnant women in the third trimester as the control group. Pre-eclamptic group consisted of mild (n = 31) and severe pre-eclamptic subgroup (n = 33). Laboratory results were compared between the groups and diagnostic usefulness of these parameters were evaluated. Results PCT, CRP, and D-Dimer levels were significantly higher in study group than the control group (P = 0.001). PCT, CRP, and D-Dimer were significantly higher in the patients with severe pre-eclampsia than mild pre-eclampsia. There were significant positive correlations between these markers and mean arterial pressure (MAP). Logistic regression analysis using the control and pre-eclampsia group showed that higher PCT (OR, 15.68; 95%-CI, 3.1578.10), CRP (OR, 14.29; 95%-CI, 3.0866.34), and D-Dimer levels (OR, 4.97; 95%-CI, 1.2220.29) were found to be risk factors significantly associated with pre-eclampsia. Conclusions This study results confirm that evidence of a possible exaggerated systemic inflammatory response in pre-eclampsia especially in severe pre-eclampsia.