Noninvasive prenatal diagnosis experience in the Cukurova Region of Southern Turkey: detecting paternal mutations of sickle cell anemia and beta-thalassemia in cell-free fetal DNA using high-resolution melting analysis


Yenilmez E. D. , TULİ A. , EVRÜKE İ. C.

PRENATAL DIAGNOSIS, vol.33, no.11, pp.1054-1062, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 11
  • Publication Date: 2013
  • Doi Number: 10.1002/pd.4196
  • Title of Journal : PRENATAL DIAGNOSIS
  • Page Numbers: pp.1054-1062

Abstract

ObjectiveThis study used a high-resolution melting (HRM) technique to detect paternal mutations for the noninvasive prenatal diagnosis (NIPD) of -thalassemia and sickle cell anemia (HbS). We also determined the levels of cell-free fetal DNA and total cell-free DNA.