Noninvasive prenatal diagnosis experience in the Cukurova Region of Southern Turkey: detecting paternal mutations of sickle cell anemia and beta-thalassemia in cell-free fetal DNA using high-resolution melting analysis


Yenilmez E. D. , TULİ A. , EVRÜKE İ. C.

PRENATAL DIAGNOSIS, cilt.33, ss.1054-1062, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33 Konu: 11
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/pd.4196
  • Dergi Adı: PRENATAL DIAGNOSIS
  • Sayfa Sayıları: ss.1054-1062

Özet

ObjectiveThis study used a high-resolution melting (HRM) technique to detect paternal mutations for the noninvasive prenatal diagnosis (NIPD) of -thalassemia and sickle cell anemia (HbS). We also determined the levels of cell-free fetal DNA and total cell-free DNA.