Dasatinib, large granular lymphocytosis, and pleural effusion: Useful or adverse effect?

Paydas S.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, cilt.89, sa.2, ss.242-247, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 89 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.critrevonc.2013.10.005
  • Dergi Adı: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.242-247
  • Anahtar Kelimeler: Dasatinib, Large granular lymphocytosis, Immune regulation, Chronic myeloid leukemia, Pleural effusion, Response, CHRONIC MYELOID-LEUKEMIA, CHRONIC MYELOGENOUS LEUKEMIA, TYROSINE KINASE INHIBITOR, CD8(+) T-CELLS, NATURAL-KILLER, NK-CELLS, CHRONIC-PHASE, ACTIVATION, IMATINIB, THERAPY
  • Çukurova Üniversitesi Adresli: Evet

Özet

Dasatinib is a second generation tyrosine kinase inhibitor approved for clinical use in first line and imatinib-resistant chronic myeloid leukemia and Philadelphia positive (Ph+) acute lymphoblastic leukemia. In addition to BCR-ABL1, dasatinib inhibits TEC kinases and SRC family kinases and is more potent than imatinib in the treatment of Ph+ leukemias. In the last 3 years, increases in cytotoxic T and natural-killer cells in peripheral blood samples have been reported in cases treated by dasatinib. The awareness of the clonal expansion of large granular lymphocytes and beneficial effect of these clonal cells increased the interest to dasatinib in cases receiving this drug. Clonal expansion of large granular lymphocytes is an important effect of dasatinib therapy, shown to be an off-target phenomenon associated with pleural effusion and better clinical response. The benefit of dasatinib-induced lymphocytosis and its underlying mechanism of this are important points for clinicians working in hematology and oncology. (C) 2013 Elsevier Ireland Ltd. All rights reserved.