Ameliorating effects of tempol on methotrexate-induced liver injury in rats

Pinar N., Kaplan M., Ozgur T., Ozcan O.

BIOMEDICINE & PHARMACOTHERAPY, cilt.102, ss.758-764, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 102
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.biopha.2018.03.147
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.758-764
  • Anahtar Kelimeler: Methotrexate, Liver injury, Tempol, INDUCED OXIDATIVE STRESS, ALPHA-LIPOIC ACID, ISCHEMIA-REPERFUSION, APOPTOSIS, INFLAMMATION, EXTRACT, KIDNEY
  • Çukurova Üniversitesi Adresli: Evet

Özet

Methotrexate (MTX) is used in the treatment of certain types of cancers and chronic inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects, the most common of which are hepatotoxicity and nephrotoxicity. In the present study, we demonstrate the protecting influence of tempol related to oxidative stress in MTX-induced liver toxicity in rats using histopathological and biochemical parameters.