Ameliorating effects of tempol on methotrexate-induced liver injury in rats

Pinar N. , Kaplan M., Ozgur T., Ozcan O.

BIOMEDICINE & PHARMACOTHERAPY, vol.102, pp.758-764, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 102
  • Publication Date: 2018
  • Doi Number: 10.1016/j.biopha.2018.03.147
  • Title of Journal : BIOMEDICINE & PHARMACOTHERAPY
  • Page Numbers: pp.758-764

Abstract

Methotrexate (MTX) is used in the treatment of certain types of cancers and chronic inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects, the most common of which are hepatotoxicity and nephrotoxicity. In the present study, we demonstrate the protecting influence of tempol related to oxidative stress in MTX-induced liver toxicity in rats using histopathological and biochemical parameters.