Ameliorating effects of tempol on methotrexate-induced liver injury in rats


Pinar N. , Kaplan M., Ozgur T., Ozcan O.

BIOMEDICINE & PHARMACOTHERAPY, cilt.102, ss.758-764, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 102
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.biopha.2018.03.147
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Sayfa Sayıları: ss.758-764

Özet

Methotrexate (MTX) is used in the treatment of certain types of cancers and chronic inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects, the most common of which are hepatotoxicity and nephrotoxicity. In the present study, we demonstrate the protecting influence of tempol related to oxidative stress in MTX-induced liver toxicity in rats using histopathological and biochemical parameters.