Ameliorating effects of tempol on methotrexate-induced liver injury in rats

Pinar N., Kaplan M., Ozgur T., Ozcan O.

BIOMEDICINE & PHARMACOTHERAPY, vol.102, pp.758-764, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 102
  • Publication Date: 2018
  • Doi Number: 10.1016/j.biopha.2018.03.147
  • Journal Name: BIOMEDICINE & PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.758-764
  • Keywords: Methotrexate, Liver injury, Tempol, INDUCED OXIDATIVE STRESS, ALPHA-LIPOIC ACID, ISCHEMIA-REPERFUSION, APOPTOSIS, INFLAMMATION, EXTRACT, KIDNEY
  • Çukurova University Affiliated: Yes

Abstract

Methotrexate (MTX) is used in the treatment of certain types of cancers and chronic inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects, the most common of which are hepatotoxicity and nephrotoxicity. In the present study, we demonstrate the protecting influence of tempol related to oxidative stress in MTX-induced liver toxicity in rats using histopathological and biochemical parameters.