Akademik Veri Yönetim Sistemi
ESMO OPEN, cilt.10, sa.3, ss.1-2, 2025 (SCI-Expanded, Scopus)
Background: Adenoid cystic carcinoma (ACC) is a rare type of malignant tumor that
most often arises in the salivary glands (particularly the minor salivary glands). The
objective of this study was to evaluate the prognostic factors associated with adenoid
cystic carcinoma originating in the major salivary glands.
Methods: This retrospective study presents a clinical analysis of our experience with
adenoid cystic carcinoma. Clinical data from 59 patients diagnosed with ACC of the
minor salivary glands between 2012 and 2020 were analyzed. The cumulative survival
rate was assessed using the Kaplan-Meier method. Survival rates were compared
through the log-rank test, and differences in the proportion of subjects between the
two groups were analyzed using the Chi-square test.
Results: Major salivary gland tumors accounted for 25.5% of the study population,
while minor salivary gland tumors constituted 74.5%. The stage distribution was as
follows: Stage I (11%), Stage II (17%), Stage III (30%), and Stage IV (42%). The overall
survival rates were 67% at 5 years and 49% at 10 years. Univariate and multivariate
survival analyses revealed that larger primary tumor size (T category), positive cervical
lymph nodes, perineural invasion, and positive surgical margins were significantly
associated with poor prognosis.
Conclusions: This retrospective study reveals that adenoid cystic carcinoma of the
salivary glands demonstrates 5-year and 10-year survival rates of 67% and 49%,
respectively. Tumor size, cervical lymph node status, perineural invasion, and surgical
margin status emerged as significant prognostic factors. These findings suggest that
early detection and complete surgical resection are crucial for improved patient
outcomes. Further multicenter studies are needed to validate these results and
optimize treatment strategies for this challenging malignancy.