In this study, Nile tilapia (Oreochromis niloticus) fed with ginger (Zingiber officinale) at different ratios for 90 days in terms of their hematological, oxidative stress and growth parameters, mortality and RPS (relative percent survival) ratios against Aeromonas hydrophila, were investigated. The blood and tissue samples (liver, gill and gut) were taken from the 120 fish in the control and ginger groups (0.5%, 0.1%, 1.0%) infected with A. hydrophila for hematological parameters, oxidative stress indices (OSI). RBC indices, Hb and Hct values, differential count (D.C.) increased significantly in the 0.5% and 1.0% ginger groups. SOD and CAT enzymes activity were reduced in the liver, gill and gut tissues in the control group, these enzymes raised in the 0.5% and 1.0% ginger groups (P<0.05). No significant differences were determined amongs the experimental groups in terms of growth parameters. On the other hand, the rate of 61.6% RPS was the best indicator of inhibition effect of 1.0% ginger on pathogen. At higher doses of ginger, the increases in hematological and oxidative stress indices, and those in the rate of RPS were considered as the best results of antibacterial and antioxidant characteristic of ginger against the A. hydrophila infection in tilapia.