The primary strategy adopted in the world for the protection of the species is the declaration of protected areas. Besides these categories, university campuses like Cukurova University are also important areas where biological diversity can be protected / maintained, as well as in areas where government institutions are located at. Cukurova University Campus, which constitutes the research area, covers an area of 1 977.26 hectares. Although this area has rich biodiversity, it is threatened by an increased structuring process. The aim of this study is to determine the effects of the buildings on the flora of the Cukurova University Campus in the context of increased education and training. In line with its objective, the campus' 1987 land uses and 2018 land uses were classified by ArcGIS 10.0 computer software. In line with the data obtained in the scope of area studies, plants were classified primarily according to the life forms of Raunkiaer, was determined to the rate of endemism on campus, and then the degree of anthropogenic change of the campus was determined. It has been determined that the areas that are habitats for many plant species, especially endemic species, are opened to construction.