Diagnostic Modalities Based on Flow Cytometry for Chronic Granulomatous Disease: A Multicenter Study in a Well-Defined Cohort.


Baris H., Ogulur I., Akcam B., Kiykim A., Karagoz D., Saraymen B., ...More

The journal of allergy and clinical immunology. In practice, vol.8, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jaip.2020.07.030
  • Journal Name: The journal of allergy and clinical immunology. In practice
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Keywords: Chronic granulomatous disease, NADPH oxidase, flow cytometry, Dihydrorhodamine, gp91, p22, p47, p67, MUTATIONS, DIHYDRORHODAMINE, OXIDASE, ASSAY, FAMILIES, CARRIERS, TURKEY, BURST
  • Çukurova University Affiliated: Yes

Abstract

BACKGROUND: Chronic granulomatous disease (CGD) is characterized by defective microbial killing due to mutations affecting subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Definitive genetic identification of disease subtypes may be delayed or not readily available.